학술저널
Dexamethasone에 의한 RANKL 유도성 파골세포 분화 촉진 효과
The Stimulatory Effect of Dexamethasone on RANKL-induced Osteoclastogenesis
- 대한약학회
- 약학회지
- 제53권 제2호 (2009년)
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2009.0478 - 82 (5 pages)
- 4
We explored the effects of dexamethasone on osteoclast precursors using BMMs. Dexamethasone inhibited the proliferation of BMMs. Furthermore, it stimulated the osteoclast formation via NFATc1 activation in the presence of RANKL. Since dexamethasone targeted the early stage of osteoclast formation, we investigated its effect on mRNA expression of GR and IFN-β. Whereas dexamethasone had no effects on GR expression in the presence of RANKL, it reduced he expression of IFN-β, suggesting that dexamethasone increased RANKL-induced osteoclast formation by modulating IFN-β.
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