학술저널
대장암 세포에서 5-FU(Fluorouracil)의 세포독성과 관련된 단백체 분석
Proteomic Approach to the Cytotoxicity of 5-FU(Fluorouracil) in Colon Cancer Cells
- 대한약학회
- 약학회지
- 제53권 제3호 (2009년)
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2009.06145 - 150 (6 pages)
- 15
We evaluated cytotoxic effect based on the MTT assay and identified altered proteins in 5-FU(fluorouracil) treated HT29 cells using two-dimensional gel electrophoresis and MALDI-TOF/TOF-MS. As proteins inducing apoptosis, siah binding protein 1 and p47 protein isoform a were up-regulated and tumor protein translationally-controlled 1 was downregulated by 5-FU treatment. And mannose 6 phosphate receptor binding protein 1 controls DNA mismatch repair system was increased. We suggest 5-FU promotes a cytotoxicity under the action of these proteins in colon cancer cells.
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