학술저널
성상세포에서 메테오린에 의한 TSP-1 발현조절에 PKCδ 신호경로의 연관성
Effect of Meteorin on the Regulation of TSP-1 via PKCδ Signalings in Astrocytes
- 대한약학회
- 약학회지
- 제53권 제3호 (2009년)
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2009.06151 - 155 (5 pages)
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Meteorin in astrocytes has antiangiogenic activities via thrombospondin-1 (TSP-1), however, the regulatory mechanism has been unclear. Here we report that Meteorin upregulates TSP transcriptionally through luciferase reporter assays in astrocytes. Moreover, Meteorin activates PKCδ and ERK1/2 in astrocytes. Inhibition of PKCδ and ERK1/2 activities attenuated expression of TSP-1 by Meteorin in astrocytes. We, therefore, demonstrate that Meteorin activates PKCδ signaling and, in turn, increases TSP-1 expression in astrocytes to inhibit angiogenesis in the brain.
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