학술저널
정공피으로부터 항염증물질의 연구
Studies on the Antiinflammatory Compounds from Sorbus Commixta
- 대한약학회
- 약학회지
- 제53권 제6호 (2009년)
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2009.12351 - 356 (6 pages)
- 12
Sakuranetin, prunetin and dihydroquercetin were isolated from the methanol extract of Sorbus commixta by 1D/2D-NMR and LC-MASS spectrometry. Medicating these compounds to RAW264.7 cell that was pre-treated by lipopolysaccharide revealed anti-inflammatory effects that greatly inhibited the production of NO (nitric oxide) and PEG2 (prostaglandin E2), which are well known to cause the expression of iNOS (inducible nitric oxide synthase) and COX-2 (Cyclooxygenase-2). These results suggest that these compounds can be used as stable anti-inflammatory materials.
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