학술저널
에스트로겐성 물질에 의해 자극된 인간 유방암 세포 증식에 대한 다이드제인, 바이칼레인, 헤스페리딘 및 우르솔산의 억제 효과
Anti-proliferative Effects of Daidzein, Baicalein, Hesperidin and Ursolic Acid on Human Breast Cancer Cells Stimulated by Estrogenic Compounds
- 대한약학회
- 약학회지
- 제54권 제3호 (2010년)
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2010.06168 - 173 (6 pages)
- 60
We investigated whether three flavonoids including daidzein, baicalein, hesperidin and ursolic acid, a triterpene acid, affect proliferation of MCF-7 human breast cancer cells stimulated by estrogenic compounds. Ursolic acid and baicalein inhibited proliferation of MCF-7 cells induced by PhIP, a food-derived carcinogen with estrogenic activity. Daidzein and hesperidin inhibited estradiol-induced proliferation of MCF-7 cells. These compounds should be further investigated for the possible involvement in signaling pathway after estrogen receptor binding in breast cancer cells.
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