학술저널
7-아릴옥시-크로만-2-카복사마이드 유도체들의 합성 및 NF-κB 저해활성
Synthesis of 7-Aryloxy-chroman-2-carboxamides and their Evaluation of NF-κB Inhibitory Activities
- 대한약학회
- 약학회지
- 제54권 제3호 (2010년)
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2010.06200 - 204 (5 pages)
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Nuclear factor-κB (NF-κB) plays critical roles in physiological and pathological processes such as immune function, cellular growth, homeostasis, apoptosis, and inflammation. As part of our ongoing efforts to develop novel NF-κB inhibitory agents, we reported that KL-1156 (6-hydroxy-7-methoxychroman-2-carboxylic acid phenylamide) exhibited potent inhibitory activity of NF-κB. For further structure-activity relationship, a series of 7-aryloxy-chroman-2-carboxylamide derivatives were synthesized to explore their inhibitory activities of NF-κB.
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