섬오가피 추출물의 항암관련 사이토카인 분비활성

Effects of Acanthopanax koreanum Extracts on Anticancer Related Cytokine Secretions

Stems and roots of Acanthopanax koreanum Nakai were extracted with water and treated on immune cells in order to determine their immunomodulatory activites. Various Th-1 type cytokines were measured using ELISA including interleukin (IL)-2, IL-12, interferon-gamma (IFN-γ), and tumor necrosis factor-alpha (TNF-α) secreted by dendritic cells, Tcells, intestinal epithelial cells, natural killer cells, and macrophages. As a result, there was a significant increase in IL-12 and IFN-γ, secretion, but there was no change in the secretion of TNF-α. Additionally T-cells slightly increased the secretion of IL-2, but there was a significant increase of IL-2 in intestinal epithelial cells. Therefore, our results suggest that A. koreanum Nakai may act as an immunomodulator by stimulating the cell-mediated immunity which can help the immune system defend against infections or cancer cells.