학술저널
히스티딘 중합체가 일차배양 기도 상피세포에서의 뮤신 유리에 미치는 영향
Effects of Histidine Polymers on Mucin Release from Primary Cultured Airway Epithelial Cells
- 대한약학회
- 약학회지
- 제54권 제5호 (2010년)
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2010.10334 - 340 (7 pages)
- 10
We investigated whether poly-L-histidine (PLH) significantly affect mucin release from cultured airway epithelial cells. Confluent primary hamster tracheal surface epithelial (HTSE) cells were metabolically radiolabeled with 3H-glucosamine for 24 hr and chased for 30 min in the presence of PLH to assess the effect on 3H-mucin release. PLH 9,850 and PLH 6,700 specifically inhibit mucin release from airway goblet cells without significant cytotoxicity. This finding suggests that poly-L-histidine might function as an airway mucoregulative agent.
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