학술저널
인간 기도 상피세포에서 증가된 뮤신 생성에 대한 쿠마린과 인도메타신의 억제작용
Suppression of Induced Mucin Production from Human Airway Epithelial Cells by Coumarin and Indomethacin
- 대한약학회
- 약학회지
- 제54권 제5호 (2010년)
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2010.10416 - 421 (6 pages)
- 16
We examined whether indomethacin, noscapine, coumarin, uridine and betaine affect airway mucin production induced by EGF or TNF-α from NCI-H292 cells. Cells were pretreated with each agent for 30 min and then stimulated with EGF or TNF-α for 24 h. Of the five compounds, coumarin suppressed airway mucin production induced by EGF or TNF-α. However, indomethacin suppressed airway mucin production induced by EGF. This result suggests that coumarin and indomethacin can regulate the production of mucin induced by EGF, by directly acting on airway epithelial cells.
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