L-형 칼슘 이온통로에 의한 파골세포 분화의 조절

The Regulation of Osteoclastogenesis by L-Type Channel Agonist

We investigated the role of L-type Ca2+ channel in receptor activator of nuclear factor-kappaB ligand (RANKL)-induced osteoclast formation. BayK 8644, a L-type Ca2+ channel agonist, was shown to increase the RANKLinduced osteoclastogenesis and actin ring formation in mouse bone marrow-dereived macrophage (BMM) culture system. BayK 8644 stimulated RANKL-induced extracellular signal-regulated kinase (ERK) and p38 MAP kinase (MAPK) activation, which leads to increased nuclear factor of activated T cells (NFAT)c1 expression. Taken together, these data indicate that L-type Ca2+ channel regulates osteoclast formation possibly through ERK- and p38-mediated NFATc1 expression.