K+ Channel 개방제인 BRL 34915의 신장작용

Renal Action of BRL 34915, a K+ Channel Opener, in Dog

The effect of BRL 34915, a K+ channel opener, on renal function was investigated in anesthetized dog. BRL 34915, when given into the vein, elicited the decrease of urine volume accompanied with the reduction of renal plasma flow (RPF), osmolar clearance (Coosm) and amounts of sodium excreted into urine (ENNa), whereas reabsorption rate of sodium in renal tubules (RNa), ratio of K+ against Na+ in urine (K+/Na+) were elevated significantly with a partial fall of mean arterial pressure (MAP). BRL 34915 injected into a renal artery produced the diuretic action along with the increase in RPF, COSM, EN, and amounts of potassium excreted in urine (EK), and the decrease in RNa, reabsorption rate of potassium in renal tubules (RK), free water clearance (CH20) and K+/Na+ ratio in only ipsilateral kidney, however changes of the renal function were not observed in control kidney. BRL 34915 given into carotid artery exhibited the same aspect as changes of renal function induced by intravenous BRL 34915. These results suggest that BRL 34915 has dual effects, renally acting diuretic and centrally acting antidiuretic action.