갑상선 엽절제술 후 갑상선염 유무에 따른 갑상선기능저하의 위험 인자: 갑상선 유두상암 환자에서의 분석

Risk Factors for Hypothyroidism after Thyroid Lobectomy with Papillary Thyroid Crcinoma according to Existence of Thyroiditis

<B>Purpose: </B>This study evaluated the risk factors for hypothyroidism after lobectomy for low risk papillary thyroid carcinoma according to existence of thyroiditis, especially on preoperative thyroid stimulating hormone (TSH) level and remnant thyroid volume. <P><B>Methods:</B> The clinical records of 169 patients who underwent thyroid lobectomy due to papillary thyroid carcinoma were reviewed. We maintain the TSH level between 0.10&#8764;0.50 mU/L with thyroid hormone until 6 to 12 months after lobectomy. Then we stopped medication and check TSH level at intervals of 2&#8764;6 months. The patients were divided into 2 groups; hypothyroid (n=63) and euthyroid (n=106) state after lobectomy. Euthyroid state was defined as an TSH level between 0.50&#8764;5.0 mU/L, hypothyroid state as an elevated TSH level above 10 mU/L and need thyroid hormone. <P><B>Results:</B> Factor for age, sex, type of operation, result of biopsy were not significant to postoperative hypothyroidism. Presence of thyroid autoantibody was significantly different (P＜0.01) in the patients with thyroiditis compared with the patients without thyroiditis. When patient had thyroiditis, there was high possibility of postoperative hypothyroidism regardless of preoperative TSH level and remnant thyroid volume (P＞0.05). When patient didn't have thyroiditis, there was high possibility of postoperative hypothyroidism when preoperative TSH is in high normal level and remnant thyroid volume ratio is below 50% (P＜0.01).</B> <TABLE BORDER=0 CELLPADDING=9 WIDTH=397 HEIGHT=122> <TD VALIGN=MIDDLE WIDTH=100%> <P><FONT SIZE=2><SPAN STYLE="font-size:10pt;">책임저자<FONT FACE="AmeriGarmnd BT"> </SPAN><FONT SIZE=2><SPAN STYLE="font-size:10pt;"><FONT FACE="AmeriGarmnd BT">: 고준완<FONT FACE="AmeriGarmnd BT">, 광주시<FONT FACE="AmeriGarmnd BT"> 남구<FONT FACE="AmeriGarmnd BT"> 양림동<FONT FACE="AmeriGarmnd BT"> 264</SPAN> <P><FONT SIZE=2><SPAN STYLE="font-size:10pt;"></SPAN> <FONT SIZE=2><SPAN STYLE="font-size:10pt;"><FONT FACE="AmeriGarmnd BT">&#9713;</SPAN><FONT SIZE=2><SPAN STYLE="font-size:10pt;"><FONT FACE="AmeriGarmnd BT">503-715, 광주기독병원<FONT FACE="AmeriGarmnd BT"> 외과</SPAN> <P><FONT SIZE=2><SPAN STYLE="font-size:10pt;"></SPAN> <FONT SIZE=2><SPAN STYLE="font-size:10pt;"><FONT FACE="AmeriGarmnd BT">Tel: 062-650-5036, Fax: 062-671-7447</SPAN> <P><FONT SIZE=2><SPAN STYLE="font-size:10pt;"> </SPAN><FONT SIZE=2><SPAN STYLE="font-size:10pt;"></SPAN> <FONT SIZE=2><SPAN STYLE="font-size:10pt;">E-mail: </SPAN><FONT SIZE=2><SPAN STYLE="font-size:10pt;">cumo94@hanmail.net</SPAN> <P><FONT SIZE=2><SPAN STYLE="font-size:10pt;">접수일：2011년 3월 5일, 수정일：2011년 6월 8일, 게재승인일：2011년 6월 11일</SPAN></TD> <CAPTION ALIGN=BOTTOM> </CAPTION> </TABLE> <P><B>Conclusion:</B> One can check the presence of thyroiditis with thyroid autoantibody and can predict the possibility of postoperative hypothyroidism after lobectomy in patients with low risk papillary thyroid carcinoma with preoperative TSH level and remnant thyroid volume. <B>(Ko</B><B></B><B>rean J Endo</B><B>crine Surg 2011;11:90-96)</B>