갑상선 유두암에서 BRAF<SUP>V600E</SUP> 돌연변이와 연관된 임상병리학적 인자 및 초음파 소견과의 연관성

Association of BRAF<SUP>V600E</SUP> Mutation with Poor Clinical Prognostic Factors and Ultrasonographic Findings in Cases of Papillary Thyroid Carcinoma

Purpose: This study evaluated the association of the BRAF<SUP>V600E</SUP> mutation with known prognostic factors and ultrasonographic characteristics in cases of papillary thyroid carcinoma. Methods: Subjects included 169 patients who received thyroidectomy at Wonju Christian Hospital under the diagnosis of papillary thyroid cancer from February 2010 to October 2011. Results: Of the total patients who received thyroidectomy, there were 128 cases (75,7%) of BRAF<SUP>V600E</SUP> mutation. Neither age nor sex were associated with the BRAF<SUP>V600E</SUP> mutation. Tumor size, shape, margin, extrathyroidal extension, central node metastasis and lateral node metastasis were found not to be associated with the BRAF<SUP>V600E</SUP> mutation. Tumor calcification, echogenicity and vascularity were also not associated with the mutation. Conclusion: As debate remains about the association between the BRAF<SUP>V600E</SUP> mutation and clincopathologic factors and ultrasonographic characteristics in cases of papillary thyroid carcinoma, further study is needed. (Ko</SUP>rean J Endocrine Surg 2012;12:16-20)