결막 평편상피 유두종 환자에서 점안 인터페론의 치료 효과

The Effect of Topical Interferon α-2b in the Treatment of Conjunctival Squamous Papilloma

Purpose: To study the effectiveness of Interferon alfa-2b (IFNα2b) for treating squamous papilloma of the conjunctiva. Methods: One million units/cc of IFNα2b was applied 4 times a day after identifying squamous papilloma by excisional biopsy. The IFNα2b was used continuously 2 to 6 months after the tumor became undetectable with the unaided eye. The dose was then tapered. Results: Three of the 4 patients had a history of recurrences (1-4 times). In one patient, the tumor was difficult to remove surgically due to the location of the tumor (around the upper punctum). The tumor disappeared with no complications or recurrences during the follow-up period. Conclusions: In patients with conjunctival squamous papilloma with frequent relapses or difficulty in excision, applying IFNα2b as an eye drop appears to be an effective form of therapy and can be used safely without complications.