다양한 각막표면질환에서 양막이식술의 임상적 효과

The Clinical Effect of Amniotic Membrane Transplantation for Various Ocular Surface Diseases

Purpose: To describe the clinical outcome of amniotic membrane transplantation(AMT) for various ocular surface diseases. Methods: We reviewed the medical records of 52 eyes from 46 patients which had underwent AMT for various ocular surface diseases. We scored each eyes from 0 to 4 for subjective symptoms (symptom score) and epithelial healing (epithelial grade) at three months after AMT. The clinical score was calculated as the symptom score time the epithelial grade. Results: The mean clinical score among all ocular surface disease was 10.41±4.26. The mean clinical scores for each disease are as follows: 7.71±3.56 for corneal ulcers, 14.43±3.1 for persistent epithelial defects, 12.83±2.71 for exposure keratitis, 12.86±3.18 for herpes keratitis, 5.85±2.5 for bullous keratopathy, 10.53±4.27 for chemical corneal burns and 16.0±0.0 for shield ulcers. Subjective symptoms subsides and epithelial healing progressed in all patients treated by AMT. No complications occurred. Conclusions: AMT is an effective method for treating various ocular surface diseases, because AMT improves the subjective symptoms of patients and promotes the healing of epithelial lesions.