각막 천공을 동반한 무렌각막궤양에 시행한 양막이식술

The Amniotic Membrane Transplantation in Corneal Perforation due to Mooren`s Ulcer

Purpose: To report patients with corneal perforation with Mooren`s ulcer treated successfully with amniotic membrane transplantation and cryotherapy. Methods: We performed conjunctival recession, permanent amniotic membrane transplantation, cryotherapy, amniotic membrane patch to treat corneal perforation associated with severe inflammatory Mooren`s ulcer of 4 eyes in 3 patients. We investigated the interval of absence of inflammation, reepithelization over grafted amniotic membrane, and restoration of visual acuity. Results: The perforated corneal lesion was sealed successfully by the amniotic membrane in 4 eyes. The complete reepithelization over grafted amniotic membrane was achieved 21±2.7 days and complete remission was achieved 94±13.0 days after surgery. There was no recurrence in 3 eyes during 21±2.7 months. A patient who recurred inflammatory impending corneal perforation underwent limbal transplantation with amniotic membrane re-transplantation, which resulted in remission after 13 months. All 3 eyes restored visual acuity Except one who developed cataract. Conclusions: Amniotic membrane transplantation may be useful in treating corneal perforation with active inflammation in Mooren`s ulcer.