치료가 잘 되지 않는 공막염에서 인플릭시맙(infliximab)의 효과 1예 보고

A Case Report of Intractable Scleritis Effectively Treated with Infliximab

Purpose: To report a case of a patient with intractable scleritis with conventional immunosuppressive therapy who showed effective treatment with infliximab. Case summary: A 71-year-old man presented with orbital cellulitis and diffuse anterior scleritis of his left eye. Although orbital cellulites showed remission with topical and systemic antibiotics, scleritis persisted despite a combination therapy of immunosuppressive agents (cyclosporin, mycophenolate, prednisolone) for 1 month. Finally, he was given infliximab (5 mg/kg) intravenously three times at 2-week intervals, after which ocular pain, chemosis, conjunctival injection, and sclera thickening considerably reduced, and scleritis completely remitted. Conclusions: The administration of Infliximab seems to be an effective therapy in patients with intractable scleritis undergoing conventional therapy. J Korean Ophthalmol Soc 2008;49(10):1690-1695