만성 B형 간염에서의 페그인터페론 치료 시 망막병증의 임상양상

Clinical Features of Retinopathy in Chronic Hepatitis B Patients With Treated With Peginterferon

Purpose: To evaluate the clinical features of retinopathy in chronic hepatitis B patients treated with peginterferon. Methods: Chronic hepatitis B patients treated with peginterferon were evaluated during regular routine ophthalmic examinations including fundus examination before and during the 1-year follow-up after treatment. A total of 88 patients were included in the study. Results: Retinopathy developed in 11 (12.5 %) out of 88 patients at a mean of 7 weeks after initiation of treatment. Peginterferon treatment was continued in all patients and retinal abnormalities including cotton wool spot, retinal hemorrhage and microaneurysm resolved without visual impairment. The incidence of hypertension between the retinopathy group and the group without retinopathy was significantly different (P = 0.020). Conclusions: The incidence of retinopathy with peginterferon in chronic hepatitis B patients was low and the prognosis was benign. Thus, routine screening for peginterferon retinopathy is not necessary. J Korean Ophthalmol Soc 2011;52(1):41-45