유리체절제술을 시행한 눈에서 난치성 당뇨황반부종에 대한 후테논낭하 트리암시놀론 주사

Posterior Subtenon Triamcinolone Acetonide Injection for Refractory Diabetic Macular Edema in Vitrectomized Eye

Purpose: To evaluate the effect of posterior subtenon injection of triamcinolone acetonide (TA) in patients with refractory diabetic macular edema (DME) after vitrectomy. Methods: Seventeen vitrectomized eyes in 16 patients with DME underwent a posterior subtenon injection of TA (40 mg/1.0 ml) and were followed-up for more than six months. Visual acuity (VA, logMAR) and central subfield macular thickness (CSMT, μm) according to optical coherent tomography were assessed at baseline and 1, 3, and 6 months after an injection of TA. Results: The patients included four men and 12 women with an average age of 56.9 years. VA improved significantly from 0.70 ± 0.33 (mean ± SD) before injection to 0.56 ± 0.24 one month and 0.54 ± 0.21 three months after an injection of TA. Visual acuity at six months was 0.61 ± 0.24 and had no significance (p = 0.17). CSMT decreased significantly from 469 ± 145 before injection to 323 ± 58, 343 ± 100, and 389 ± 156 one, three, and six months after an injection of TA, respectively. Conclusions: Posterior subtenon injection of TA is effective in the short-term for improving VA and CMT in patients with refractory diabetic macular edema after vitrectomy. J Korean Ophthalmol Soc 2011;52(7):832-837