건성안 환자에서 쇼그렌증후군의 빈도 및 임상양상

Prevalence and Clinical Aspects of Sjögren Syndrome in Dry Eye Patients

Purpose: To investigate the prevalence and clinical aspects of Sj&ouml;gren syndrome in patients who were diagnosed with dry eye syndrome in Korea. Methods: The medical records of patients who were diagnosed with dry eye syndrome in a dry eye clinic during a 2-year period (March 2008 to March 2010) and were followed up for more than 3 months were reviewed retrospectively. Results: A total of 206 patients were included in the present study. Fifty-eight patients (28%) had Sj&ouml;gren syndrome and 39 patients (19%) showed primary Sj&ouml;gren syndrome. Sj&ouml;gren syndrome patients showed poorer results than non-Sj&ouml;gren syndrome patients in ocular surface disease index score (OSDI), tear break up time, Schirmer test score, and ocular surface staining score using the Oxford scheme (p < 0.05). Among the patients with primary Sj&ouml;gren syndrome, 27 patients were SSA (anti-Ro antibodies) or SSB (anti-La antibodies) positive and 12 patients were sero-negative. There were no statistically significant differences in objective or subjective parameters between the sero-positive and sero-negative groups. Conclusions: Sj&ouml;gren syndrome was observed in 28% of all dry eye patients, in two-thirds of severe dry eye patients. Sj&ouml;gren syndrome patients showed more severe clinical aspects than dry eye patients with non-Sj&ouml;gren syndrome. Diagnosing Sj&ouml;gren syndrome through systemic evaluation is necessary in the patients with severe dry eye. J Korean Ophthalmol Soc 2012;53(4):499-504