안구건조증에서 히알우론산 단독치료와 사이클로스포린 A의 병합치료가 눈물막에 미치는 효과

Effect of Sodium Hyaluronate and Cyclosporine A on Tear Film in Dry Eye Syndrome

Purpose: To evaluate the efficacy of topical 0.1% hyaluronate (HA) and 0.05% cyclosporine A on tear film parameters in dry eye syndrome patients. Methods: Patients who were diagnosed with dry eye syndrome were treated with 0.1% HA only (Group 1, 46 eyes) or 0.1% HA combined with cyclosporine A (Group 2, 54 eyes). Ocular surface disease index (OSDI), tear film break-up time (BUT), Schirmer’s test, and tear osmolarity were evaluated before treatment and at 1, 2, 3, and 6 months after treatment. Results: OSDI was significantly improved at 2 months after treatment and Schirmer’s test results significantly improved at 1 month after treatment in both groups. The BUT was significantly improved 3 months after treatment in Group 1 and at 1 month after treatment in Group 2. Tear osmolarity significantly improved at 1 month after treatment in both groups, but continuously improved up to 6 months after treatment only in Group 2. The BUT and Schirmer’s test showed greater improvements in Group 2 than in Group 1. Conclusions: Combined treatment of topical 0.1% HA and 0.05% cyclosporine A may be more effective for improving dry eye syndrome.