당뇨망막병증 및 당뇨황반부종환자에서의 중증도에 따른 전방수내 사이토카인 상관관계 분석

Analysis of Intraocular Cytokines According to Progression of Diabetic Retinopathy and Macular Edema in Diabetic Patients

Purpose: To investigate the relationship between the aqueous concentrations of cytokines, chemokine, VEGF and the severity of diabetic retinopathy and diabetic macular edema. Methods: Sixty eyes with diabetic retinopathy and diabetic macular edema, and 10 eyes of nondiabetic subjects were followed for 6 months. The aqueous levels of inflammatory and anti-inflammatory factors were measured. The aqueous levels of cytokines were investigated according to the severity of diabetic retinopathy and diabetic macular edema. Results: The aqueous levels of IL-6, IL-8, IL-10, MCP-1, and VEGF were elevated according to the severity of diabetic retinopathy. The aqueous levels of IL-13 were higher in eyes of diabetic patients than in eyes of nondiabetic subjects, but there were no statistically significant difference between diabetic retinopathy and nondiabetic subjects. The aqueous levels of IL-6, MCP-1, and VEGF were positively correlated with central macular thickness in eyes with diabetic macular edema. Conclusions: The aqueous levels of IL-6, IL-8, IL-10, MCP-1, and VEGF were correlated with the severity of diabetic retinopathy. The aqueous levels of IL-6, MCP-1, and VEGF were positively correlated with the severity of macular edema.