Co-treatment with phytochemicals or drugs is a promising approach to enhance the chemoprevention and chemotherapy in some diseases. Combination of compounds may overcome multidrug resistantance, decrease the effective dose of individual drug, reduce side effects and achieve clinical success. Tea (Camellia sinensis (L.) O. Kuntze, Theaceae) is second only to water in popularity as a beverage in the world, and its health benefits are mostly attributed to tea polyphe nols. This review has summarized the synergistic effects of tea polyphenols with other phytochemicals or drugs on antioxidation, anti microorganism, anticancer, improvement of neurodegenerative diseases and other functions including protection from nephrotoxicity, inhibition of sporozoite survival, promotion of hematopoietic stem cell proliferation, improvement of bone mass and weight maintenance. The synergism of tea polyphenols with other compounds indicates that combination of tea polyphenols with other agents is a promising approach for treatment of some diseases. In addition, the synergistic bioactivities of tea polyphenols with other phytochemicals or nutrients may overcome the poor bioavailability of tea polyphenols in vivo, and provide a new explanation for the health benefits of tea.
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