Anti-atopic Dermatitis Effect of the Black Tea Extracts in Animal Model

This study investigated whether the black tea extracts have anti-atopic dermatitis activity in mouse model. The 2, 4-dinitrochlorobenzene (DNCB) treated to male BALB/c mice to evaluate atopic dermatitis symptoms. The 6 weeks old selected five mice were shaved around dorsal regions then atopic dermatitis was induced by 1.5% DNCB two times treatment for one week. The black tea extracts were orally administrated (200 ~ 800 mg/kg) once a day for 6 weeks. To evaluate atopic dermatitis, the clinical dermatitis score test was performed, which is an eye observatory method for erythema, hemorrhage, dryness, scarring, lichenification and erosion. The sum of 6 category scores presented degree of the symptoms. The weight change of the mice during validity evaluation periods (6 weeks) was not shown. The atopic symptoms such as erythema, dryness, erosion lichenification appeared evenly after 2 weeks DNCB treated mice. The clinical dermatitis score showed 8 on 2 weeks treated mice and the score increased up to 11 after 3 weeks. On the other hand, the black tea extracts treated mice revealed that the symptoms decreased and not increased in the score even after 2 weeks. The results suggest that the black tea extracts reduce atopic dermatitis and may have positive role in the inflammation-mediated immune reaction.