원발급성폐쇄각발작에서 스펙트럼 빛간섭단층촬영을 이용한 황반부 신경절세포-내망상층의 두께변화

Change in the mGC-IPL in Patients with a History of APAC According to SD-OCT

Purpose: This study was conducted to measure macular ganglion cell-inner plexiform layer (mGC-IPL) thickness in patients with a history of unilateral single attack of acute primary angle closure (APAC) and to compare it with that of unaffected fellow eyes 8 weeks after resolution using spectrum domain optical coherence tomography (SD-OCT). Methods: Medical records of 24 patients with history of first episode of unilateral APAC were reviewed retrospectively. Eight weeks after APAC, mGC-IPL thickness and peripapillary retinal nerve fiber layer thickness were measured with SD-OCT and analyzed in eyes affected by APAC (group 1) and fellow eyes (group 2). Results: There were no significant differences between the groups with regard to best corrected visual acuity, spherical equivalent, central corneal thickness, or axial length (<em>p</em> &gt; 0.05). There were no significant differences in mGC-IPL thickness in the superotemporal, superior, or superonasal sectors (<em>p</em> &gt; 0.05). However, average, inferonasal, inferior, and inferotemporal sectors of group 1 were significantly thinner than those of group 2 (<em>p</em> = 0.002, 0.002, 0.001, 0.001, respectively). In addition, average mGC-IPL difference between affected eyes and fellow eyes showed a statistically significant correlation with attack duration (correlation coefficient = 0.249, <em>p</em> = 0.019). Conclusions: Normalization of elevated intraocular pressure as soon as possible after APAC onset is recommended in order to reduce mGC-IPL loss, and measurements of mGC-IPL thickness can be helpful for follow-up of APAC patients. J Korean Ophthalmol Soc 2014;55(8):1167-1173