굴절교정레이저각막절제술 후 트라닐라스트의 각막혼탁 억제에 대한 펜타캠을 이용한 분석

Effects of Topical Tranilast on Corneal Haze with the Pentacam; after Photorefractive Keratectomy

Purpose: To evaluate the inhibitory effect of tranilast on formation of corneal haze using the Pentacam<SUP>&#9415; after photorefractive keratectomy (PRK). Methods: A prospective, randomized, paired eye study was performed. A total of 60 eyes from 30 patients were enrolled in the present study. Eyes were categorized as myopic eyes &lt;-5 D and ≥-5 D. Patients undergoing PRK were randomized to receive tranilast in one eye and no medication in the contralateral eye. Three months postoperatively, corneal haze was measured with the Pentacam<SUP>&#9415;and compared between the 2 groups. Results: Statistical differences were not found in preoperative data in the tranilast or control groups (all <EM>p</EM> &gt; 0.05). There was a strong decreasing density trend from the apex to the 3 mm radius in both groups (<EM>p </EM>&lt; 0.05). However, postoperative corneal haze in the tranilast group was similar to the control group (<EM>p </EM>&gt; 0.05). Conclusions: The use of tranilast after PRK did not inhibit corneal opacity. Additionally, Pentacam<SUP>&#9415; can provide a useful objective measure of corneal haze. J Korean Ophthalmol Soc 2014;55(9):1277-1283