Association Between Earlobe Crease and the Metabolic Syndrome in a Cross-sectional Study

OBJECTIVES: Several studies found a significant association between earlobe crease (ELC) and cardiovascu-lar disease (CVD). Metabolic syndrome (MS) is a group of high-risk factors that are a collection of cardiovas-cular risk factors. Scant data are available about the relationship between ELC and MS. The purpose of the cur-rent study was to examine the correlation between ELC and MS. METHODS: A cross-sectional study was performed on 3,835 subjects (1,672 females, 43.6%) aged 20 to 79 years who visited a health promotion center. To increase the reliability of the diagnosis of MS, both the modi-fied Na tional Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) and International Dia-betes Federation (IDF) criteria were applied. Independent association between ELC and MS was assessed us-ing multiple logistic regression analysis after adjusting for confounding variables. RESULTS: The frequency of ELC was 20.89% and the prevalence of MS was 11.03% (NCEP criteria) and 9.75% (IDF criteria). The prevalence of both ELC and MS significantly increased with age. The modified Framingham risk score was significantly higher in subjects with ELC than without. After adjusting for conventional risk fac-tors for CVD, the risk of MS increased significantly in the presence of ELC. CONCLUSION: The current study showed that the odds ratio for MS increased in the presence of ELC in Ko-rean adults. ELC is an auxiliary indicator of MS, although prognostic value might be limited. Further studies are warranted to elucidate the clinical significance of ELC.