SB-Injection, an anticancer agent prepared from the roots of

In a medicinal practice in Puyeo, Chungnam /Korea, a preparation made from the roots of Pulsatilla koreana, Panax ginseng and Glycyrrhiza glabra has been used to treat various cancers. It was previously reported that SB31 , a preparation consisting of the extracts from the roots of Pulsatilla koreana, Panax ginseng and Glycyrrhiza glabra, exhibited cytotoxic activity against some human cancer cell lines (Kim et a/., 1994, 1995), and potent antitumor activity on ICR mice bearing S (sarcoma)-180 cells (unpublished data). We are going to present the R&D procdures includjng the measurement of antitum or activity, isolation of main antitumor component as well as the results of the preclinical and phase I clinical studies.