The Blood and Tissue Distribution of Paclitaxel after Oral Administration of Mucoadhesive Formulation

Paclitaxel formulations for oral administration were prepared. These liquid type oily formulations can be taken as is without dilution. Preliminary studies show that oral formulation had superior antitumor efficacy and high bioavailability. The tissue distribution of paclitaxel was determined after peroral administration of mucoadhesive paclitaxel formulation. The paclitaxel formulation comprising monoglyceride, triglyceride and tween 80 was administered orally to female Balb/c mice. After the administration, paclitaxel was widely distributed in various organs, and maximum drug levels were achieved in 2 h in most tissues. The paclitaxel concentration was the highest in the liver. More than 5 % of the administered drug was found in this organ.