학술저널
메틸크로만-2-카르복실산 N-(이치환)페닐아마이드 유도체의 NF-κB 저해 구조-활성 상관 관계
Structure Activity Relationship of Methylchroman-2-carboxylic Acid N-(Disubstituted)phenylamide Derivatives as Potential NF-κB Inhibitors
- 대한약학회
- 약학회지
- 제55권 제2호 (2011년)
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2011.04154 - 159 (6 pages)
- 4
During the search for a novel compound that can inhibit NF-κB activation, 6-hydroxy-7-methoxychroman-2- carboxylic acid phenyl amide (KL-1156) was identified as a good inhibitor of NF-κB activation. In the present study, we describe the synthesis of methylchroman-2-carboxylic acid N-(disubstituted)phenylamide derivatives (1 and 2 serieses). In addition, their inhibitory effects of NF-κB are compared with activity of KL-1156 and SAR (structure activity relationship) are explored.
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