학술저널
항염증효과를 갖는 2'-하이드록시찰콘 유도체의 합성
Synthesis of Anti-inflammatory 2'-Hydroxychalcone Derivatives
- 대한약학회
- 약학회지
- 제55권 제5호 (2011년)
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2011.10367 - 373 (7 pages)
- 11
It was reported that the potency of TMMC derivatives was related to the presence of the 2'-hydroxy group on the A ring. Also, 4-dimethylamino group on the B ring lowered the anti-inflammatory potency of the chalcones. We synthesized various derivatives of 2'-hydroxy chalcones having other substituents on B ring. The synthetic derivatives showed the more potent anti-inflammatory effect, comparable to that of the TMMC derivatives reported previously.
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