학술저널
헤테로 고리를 갖는 크리신 유도체의 합성 및 항염증 작용에 대한 평가
Synthesis of Chrysin Analogs with a Heteroaryl Group and Evaluation for their Anti-inflammatory Activities
- 대한약학회
- 약학회지
- 제55권 제6호 (2011년)
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2011.12462 - 465 (4 pages)
- 12
Chrysin analogs with 2-heteroaryl groups were synthesized and evaluated for their inhibitory activities against PGE2 and NO production from LPS-induced RAW 264.7 cells. Chrysin analogs were synthesized from 2-hydroxy-4,6- dimethoxy-acetophenone and heteroaryl aldehydes in 3 steps. The tested chrysin analogs showed decreased inhibitory activity against PGE2 and NO production than those of chrysin.
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