학술저널
쿠마린 유도체의 아세틸콜린 에스테라제 저해활성 연구
Study on the Acetylcholinesterase Inhibitory Activity of Coumarin Derivatives
- 대한약학회
- 약학회지
- 제55권 제6호 (2011년)
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2011.12473 - 477 (5 pages)
- 44
Alzheimer's disease (AD), one of the most common forms of dementia, is a progressive neurodegenerative disorder symptomatically characterized by the decline in memory and cognitive abilities. To date, the successful therapeutic strategy to treat AD is to maintain the levels of acetylcholine (ACh) by inhibiting acetylcholinesterase (AChE) to lead five drugs in clinical use. In this study, several coumarin derivatives were designed based on the lead structure of scopoletin and evaluated for their AChE inhibitory activities.
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