학술대회자료
페닐알킬 피페라진 유도체 합성과 α-Glucosidase 저해활성
Synthesis and α-Glucosidase Inhibitory Activity of Phenylalkyl Piperazine Analogues
- 대한약학회
- 추계총회 및 학술대회
- (2002년) vol.2
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2002.10446 - 450 (5 pages)
- 16
As an effort to find a new scaffold for α-glucosidase inhibition, we have prepared total 11 phenylalkylated piperazine derivatives and tested their α-glucosidase inhibitory activities. Compounds 8 (IC50=2.73±0.075 mM) possessing two 3-methoxyphenethyl group on 1,4-position of piperazine showed comparable potency to acarbose used as reference. But other compounds were inactive to α-glucosidase. The result indicated that proper substituents on the piperazine can engender α-glucosidase inhibitory activities on the piperazine derivatives.
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