모집단 약물동태학 방법에 의한 겐타마이신 약물동태에 미치는 환경의 영향

Enviromental Influences on Gentamicin Pharmacokinetics by Using Population Pharmacokinetic Methods

Enviromental differences in gentamicin pharmacokinetics by using population pharmacokinetic methods were compared with 20 Korean patients and 24 Korean-American appendicitis patients. Two to six blood specimens were collected from all patients at the following times : just before a regularly scheduled infusion and at 0.5 hour after the end of a 0.5 hour infusion. Nonparametric expected maximum (NPEM) algorithm for population modeling was used. The estimated parameters were the elimination rate constant (K), the slope (KS) of the relationship between K versus creatinine clearance (Ccr), the apparent volume of distribution (V), the slope (VS) of the relationship between V versus weight, gentamicin clearance (CL) and the slope (CS) of the relationship between CL versus Ccr and the V. The output includes two marginal probability density function (PDF), means, medians, modes, variance and CV%. The mean K (KS) were 0.402±0.129 h-1 (0.00486±0.00197 [h · ml/min/1.73 m2]-1) and 0.411±0.135 h-1 (0.00475±0.00180 [h · ml/min/1.73 m2]-1) for Korean and Korean-American populations, respectively. The mean V (VS) were not different at 14.3±3.6 l (0.241±0.0511 l/kg) and 15.1±3.84 l (0.239±0.0492 l/kg) for Korean and Korean-American populations, respectively (p>0.2). The mean CL (CS) were 5.68±1.69 l/h (0.0714±0.0222 l/kg [h · ml/min/1.73 m2]) and 5.70±1.77 l/h (0.0701±0.0215 l/kg [h · ml/min/1.73 m2]) for Korean and Korean-American populations, respectively. There were no enviromental differences in gentamicin pharmacokinetics between Korean and Korean-American appendicitis patients.