학술저널
동충하초에서 분리된 신규 항암물질의 효율적 합성법 개발
Development of an Efficient Synthetic Method for a Novel Anticancer Substance Isolated from Insect-flower
- 대한약학회
- 약학회지
- 제56권 제2호 (2012년)
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2012.0471 - 73 (3 pages)
- 31
Cordyceps militaris, a caterpillar-grown traditional medicinal mushroom, produces important bioactive compounds, cordycepin (3'-deoxyadenosine) and militarin. Militarin is reported to possess anticancer activities against several tumor cells. An efficient synthetic method of militarin was developed to prepare muti-gram scale sample for bioassay. Militarin was successfully synthesized from commercial starting materials in 5 steps and 29.3% overall yields.
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