학술저널
LC/MS/MS를 이용한 혈장 중 리도카인의 정량 및 리도카인 패치제의 약물동태학적 평가
LC/MS/MS Method for the Determination of Lidocaine in Hairless Rat Plasma and Pharmacokinetic Applications of Lidocaine Patch
- 대한약학회
- 약학회지
- 제56권 제3호 (2012년)
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2012.06158 - 163 (6 pages)
- 46
Lidocaine has been studied for many chronic pain conditions, including postherpetic neuralgia (PHN) and recently it has also been increasingly used in transdermal drug delivery systems. In this study, harmacokinetics of a lidocaine patch was studied in four hairless male rats. The plasma concentration was determined by a validated LC/MS/MS method after applying a 3×2 cm2 (30mg) patch for 12 hours. From the plasma lidocaine concentration vs time curves, AUC0-20h, Cmax, and Tmax of lidocaine patch were 2,926.32±335.28 ng · h/ml, 256.86±29.63 ng/ml, and 6.00±2.31 h, respectively.
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