종양괴사인자로 유도된 기도 뮤신 생성, 뮤신 유전자 발현 및 NF-κB p65의 핵으로의 이동에 대한 크리신의 영향

Effect of Chrysin on Tumor Necrosis Factor-α-induced Mucin Production, Mucin Gene Expression and Translocation of Nuclear Factor-kappa B in Cultured Airway Epithelial Cells

Chrysin and chlorogenic acid are natural products derived from Scutellariae Radix and Lonicerae Flos, respectively. We examined whether chrysin and chlorogenic acid affect airway mucin production induced by TNF-α in NCI-H292 cells. Cells were pretreated with each agent for 30 min and then stimulated with TNF-α for 24 h. Of the two compounds, chrysin suppressed airway MUC5AC mucin production. Also, chrysin suppressed MUC5AC mucin gene expression and translocation of NF-κB p65 induced by TNF-α. This result suggests that chrysin can regulate the production and gene expression of mucin induced by TNF-α through the inactivation of NF-κB in airway epithelial cells.