새로운 사이클로프로필 뉴크레오사이드 유도체의 합성과 생리활성
Synthesis of Novel Cyclopropyl Nucleoside Derivatives as Potential Antiherpetic Agent

대한약학회
약학회지
제56권 제4호 (2012년)
2012.08

230 - 235 (6 pages)

Synthesis of novel cyclopropyl pyrimidine and purine nucleoside derivatives 2~8 with α-configuration was successfully accomplished using an epoxide-ring opening reaction, lactonization, a hydroboration-oxidation reaction and a Mitsunobu reaction as the key steps. Antiviral activities against HSV-1 and -2, HIV-1 and -2, coxsackie B1and B3 viruses and poliovirus were assayed. Three compounds 4, 7 and 8 exhibit cytotoxicity-derived antiviral activity only in HIV-1 and -2.

새로운 사이클로프로필 뉴크레오사이드 유도체의 합성과 생리활성
Synthesis of Novel Cyclopropyl Nucleoside Derivatives as Potential Antiherpetic Agent

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새로운 사이클로프로필 뉴크레오사이드 유도체의 합성과 생리활성 Synthesis of Novel Cyclopropyl Nucleoside Derivatives as Potential Antiherpetic Agent

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새로운 사이클로프로필 뉴크레오사이드 유도체의 합성과 생리활성
Synthesis of Novel Cyclopropyl Nucleoside Derivatives as Potential Antiherpetic Agent

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