오미자 리그난 화합물의 베타-아밀로이드간 결합 억제 및 해리 효과

Effect of Lignan Components from Schizandra chinensis on Beta-amyloid Aggregation Inhibition and Dissociation

The present study tested the effect of Schizandra chinensis lignan compounds, Gomisin A and Schizandrin, on the aggregation and dissociation of beta-amyloid (Aβ)1-42 to explore a possible therapeutic target for Alzheimer's disease. Gomisin A significantly inhibited the Aβ1-42 aggregation in a dose dependent manner, but did not induced the dissociation of aggregated Aβ1-42. On the other hand, Schizandrin significantly suppressed the aggregation and dissociation of Aβ1-42. These results suggest that Gomisin A and Schizandrin, which are known as biologically active ingredients from Schizandra chinensis, may be potentially useful target molecules to develop a drug for the prevention or treatment of Alzheimer's disease.