Isoflavone-Free 검은콩펩타이드의 항고혈압 및 ACE 활성 억제효과

Antihypertensive and ACE Inhibitory Effects of Novel Isoflavone-free Black Soy Peptide Mixture

Antiobesity, hypotriglyceridemic and antihypertensive activities of isoflavone-free peptide mixture (black soybean peptide, BSP) were reported in our previous experiments. In the present study, angiotensin converting enzyme inhibitory (ACEi) activity was decreased in the aorta tissues of spontaneously hypertensive rats (SHRs) treated with BSP (1% in drink water) for 4 weeks, but not in serum. BSP administration significantly decreased ACE activity by 17.5% (from 33.2±4.5 to 27.4±1.96 mUnit/mg, p=0.0013) in aorta tissue hydrolysate. BSP treatment also decreased significantly mean blood pressure (BP) (from 213.0±16.96 to 184.0±6.53 mmHg, p<0.0001) as expected. These results indicate that BSP has antihypertensive activity as well as ACEi activity.