고지방식이 섭취 마우스에서 간 중성지방 축적의 시간에 따른 변화 : 인슐린저항성 지표들과의 상관관계 분석

Time Course Changes in Hepatic Fat Accumulation in High Fat Diet-fed C57BL/6 Mice : Comparison Analysis to the Markers of Systemic Insulin Resistance

Liver is the major organ to regulate the systemic glucose homeostasis and insulin resistance. Excess energy intake leads to triglyceride accumulation in adipose tissue first and subsequent accumulation in liver, resulting in obesity and type 2 diabetes. The representative pathological animal model for obesity associated insulin resistance is a high fat diet (HFD) fed mice model. Given the essential role of liver fat accumulation in developing systemic insulin resistance in obesity, I measured the liver triglyceride contents in HFD fed mice as a function of time. As such, in this report, I show the cause and effect relationship with regard to time during a HFD feeding between a variety of factors that are related to systemic insulin resistance including glucose intolerance, plasma insulin level and inflammatory gene expression in liver and adipose tissue.