학술저널
위스타 랫드의 충동성 조절에 대한 세로토닌의 역할
Serotonin as a Possible Modulator of Impulsive Behavior in Wistar Rats
- 대한약학회
- 약학회지
- 제59권 제4호 (2015년)
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2015.08184 - 189 (6 pages)
- 73
We compared impulsive behaviors in Wistar rats and in Wistar-Kyoto rats. There was no significant difference in locomotor activity between them. However, Wistar rats showed high activity in 5-choice serial reaction time track. When Wistar rats were treated with atomoxetin (3 mg/kg), methylphenidate (2 mg/kg) or amphetamine (2 mg/kg), they showed less impulsive behavior. Serotonin contents in prefrontal cortex and brain stem also increased. In conclusion, we suggest that Wistar rats could be used as animal model for impulsive behavior analysis. In addition, serotonin might be related with this impulsivity.
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