증상 안정기의 노년기 우울증에서 심혈관 위험과 인지기능 장애 간의 관련성 : 예비연구

Cognitive Impairments in Clinically Stable Late-Life Depression :Relationship to Cardiovascular Risk : A Pilot Study

Objective：The purpose of this study was to test the hypothesis that cardiovascular risk is associated with cognitive impairments in clinically stable late-life depression. Methods：A total of 59 clinically stable late-life depression patients over age 60 were enrolled in a cross-sectional study. Evalu-ation tools used in this study include Hamilton Rating Scale for Depression, Geriatric Depression Scale, State-Trait Anxiety Inven-tory, the Framingham general cardiovascular disease risk profile and the cognitive function battery designed for this study. Corre-lation analysis, analysis of variance and analysis of covariance were performed. Results：Patients with higher cardiovascular risk performed significantly poorer in the domains of executive function and short-term or long-term memory. In models adjusted for age, sex, education, 10% higher cardiovascular risk was associated with poorer executive function. Conclusion：Our findings suggested that cardiovascular risk could be a significant factor associated with poor executive func-tion in clinically stable late-life depression and the management which is necessary as a component of treatment planning. This pi-lot study provided good prospects for future studies to document this relationship on larger samples.