경도인지장애에서 추체외로 증상과 영역별 인지기능 저하 :A Clinical Research Center for Dementia of South Korea (CREDOS) Study

Extrapyramidal Signs and Impairment of Cognitive Subdomains in Mild Cognitive Impairment : A Clinical Research Center for Dementia of South Korea (CREDOS) Study

Objective：This study investigated the association between extrapyramidal signs (EPS) and five cognitive sub-domains in a large number of patients with mild cognitive impairment (MCI). Methods：Our analyses considered 1,943 patients with MCI drawn from the nationwide Clinical Research of Dementia of South Korea study. EPS were defined as presence in patients with at least 1 of 11 operationally specified features. We assessed five cognitive sub-domains : attention, language, visuospatial function, memory, and frontal/executive function using the Seoul Neuro-psychological Screening Battery-Dementia version. The associations of EPS with each cognitive sub-domain were analyzed with a multiple linear regression model after controlling for confounding factors : sex, age, education years, diabetes, hypertension, sever-ity of global function, depressive symptoms, and white matter hyperintensities (WMH). Results：138 MCI patients (7.1%) had EPS. This group had more global cognitive deterioration and severe WMH. MCI pa-tients with EPS showed lower performance compared to those without EPS in 3 cognitive sub-domains: attention (p=0.05), vi-suospatial function (p=0.02), and frontal/executive function (p<0.0001). The language sub-domain and the memory sub-domain did not differ between the EPS positive and the EPS negative groups. Conclusion：EPS in MCI are associated with greater cognitive impairment in specific functional sub-domains rather than with global greater cognitive deterioration.