뇌혈관질환이 없는 노년기 우울증 환자에서 피질 두께의 감소

Reduced Cortical Thickness in Patients with Late Life Depression without Cerebral Vascular Disease

Objective：The aim of this study is to compare cortical thickness in late life major depression patients without cerebral vascular disease (CVD) with that of non-depressed normal comparison subjects using magnetic resonance imaging (MRI). Methods：Altogether, 47 subjects were finally recruited from the Memory impairment clinics of Pusan National University Hospital in Korea. All subjects (late life major depression patients without CVD : n=21, matched non-depressed normal compari-son subjects : n=26) underwent 3-tesla MRI. Results：Late life major depression patients without CVD showed reduced cortical thickness in left precuneus, left inferior temporal gyrus, and left cuneus compared with non-depressed normal comparison subjects. Conclusion：Our findings suggest that late life major depression without CVD is associated with reduced cortical thickness.