천궁의 품질평가를 위한 유효성분의 함량분석

Quantitative Analysis for the Quality Evaluation of Active Ingredients in Cnidium Rhizome

The current definition of Cnidium Rhizome is the rhizome or the rhizome which is blanched by hot water of Cnidium officinale Makino or Ligusticum chuanxiong Hort. in the Korean Pharmacopoeia. However, the marker compound of Cnidium Rhizome is not specified, there are difficulties for quality control. Therefore, in this study we established the simultaneous determination method that analyze 4 different compounds by the HPLC-PDA. These compounds comprise chlorogenic acid, ferulic acid, senkyunolide A and z-ligustilide. As the result of the analysis, z-ligustilide has been shown highest content followed by senkyunolide A, ferulic acid and chlorogenic acid. These results can be exploited for a basic marker compounds of Cnidium Rhizome and for the legislation on the regulation and control of herbal medicines.