학술저널
페닐피리딜부테노이드 이량체의 합성 및 일산화질소 생성 억제작용
Synthesis of Phenylpyridylbutenoid Dimers and their Inhibitory activity against NO Production
- 대한약학회
- 약학회지
- 제60권 제6호(2016년)
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2016.12285 - 289 (5 pages)
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DOI : 10.17480/psk.2016.60.6.285
- 40
Several naturally occurring phenylbutenoid dimers were reported to possess anti-inflammatory activity. Three phenylpyridylbutenoid dimers(#1, #2 and #3) were synthesized and evaluated for their inhibitory activities against NO production from LPS-induced RAW 264.7 cells. None of the tested phenylpyridylbutenoid dimers showed any inhibitory activity against NO production, exhibiting cytotoxicity at a concentrated(100 μM) dose. These results imply that substitution of the benzene ring-A of the natural phenylbutenoid dimer(R=OMe) to a less hydrophobic pyridyl group results in loss of bioactivity.
Abstract
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