PhATE™ 모형을 적용한 금강수계 중 의약물질 농도 추정

Predicting Environmental Concentrations of Selected Pharmaceuticals Using the PhATE™ Model in Keum-River, Korea

In reεent years, pharmaceuticals in the aquatic environment have become a matter of increasing public concεm. Environmental sk assessment (ERA), including an exposure assessment, is considered the best scientifically basεd approach for evaluating the potential effects of pharmaceuticals on ecosystεms. Computerized exposure models constitute an important tool in predicting environmental exposures of pharmaceuticals. This papεr presents the applicability of an exposure model by comparing measured data of selected pharmaceuticals with predicted environmental concentrations from an exposure model. PhATE™ (Pharmaceutical Assessment and Transport Evaluation) model developed by the Pharmaceutical Research and Manufacturers of America (PhRMA) was adapted to run simulations for the Keum River. A set of 7 pharmaceuticals of high production in Korea was modeled. The PECs generated by the PhATE1M model that were then compared to the measured concentrations. The PhATE7M model predicted concεntrations for 7 pharmaceuticals including acεtarninophen， acetylsalicylic acid, erythromycin, ibuproflεn， lincomycin, mefenamic acid, and naproxen were in good agreemεnt with actual measured concentrations, which demonstrated the utility of PhATE1M as a predictive tool. 1n conclusion, PhATE1M, although it does not intend to accurately represent reality, could be utilizεd for rapid prε， dictions of the environmental concentrations of pharmaceuticals.