CO₂ 레이저와 일반 수술도를 이용한 백서의 부분적설 절제술 후의 창상치유에 관한 비교연구

COMPARATIVE STUDY OF WOUND HEALING FOLLOWING PARTIAL GLOSSECTOMY OF RAT TONGUE USING CO₂ LASER AND SCALPEL

Object This study is focused on the comparison between CO₂ laser and scalpel by examining the overal process of wound healing after partial glossectomy of rats so that the result from the research could be easily applied to actual clinical environment. Method and Material In this research, 2mm defect was formed on both lateral borders of the tongue of rats by using CO₂ laser and scalpel respectively. 4rats were sacrified each time on the 1st, 2nd, 4th, 7th, 14th and 21th day according to a general method. After fabricating 5μm paraffin specimen, H&E staining and MT staining were performed. Results Compared to scalpel, wound healing by CO₂ laser leads to a earlier initiation of vascular proliferation and re-epithelization. Therefore, some influence is exerted on the early stage of wound healing. However, the two methods seem to undergo the similar healing process.